Efficacy of Boesenbergia rotunda Treatment against Thioacetamide-Induced Liver Cirrhosis in a Rat Model

Table 4

Effect of BR ethanol extract on plasma levels of specific liver enzymes at the end of the 8-week study.

Treatment	AP IU/L	ALT IU/L	AST IU/L	LDH IU/L
Group 1; (normal rats)	79.28±0.58	30.57±1.51	70.35±0.21	490.97±3.90
Group 2; (rats with cirrhosis)	270.50±4.88 **	150.42±2.60 **	250.88±2.99 **	991.72±5.01 **
Group 3; (silymarin-treated rats)	83.85±1.06	31.62±0.63	70.35±0.43	546.33±10.46
Group 4; (treatment with the BR extract at 250 mg/kg dose)	110.22±0.49 *	91.02±1.61 *	106.00±2.59 *	792.00±3.51 *
Group 5; (treatment with the BR extract at 500 mg/kg dose)	86.13±0.56 *	33.42±0.56 *	71.10±0.78 *	574.00±5.34 *

AP: alkaline phosphatase; ALT: alanine transferase; AST: aspartate transferase; LDH lactate dehydrogenase. Means between the silymarin-treated Group 3, low-dose BR-treated Group 4, and high-dose BR-treated Group 5 had significant differences when compared with the cirrhosis control Group 2 with *𝑃<0.001 and compared with the normal control Group 1 with **𝑃<0.001.