Evidence-Based Complementary and Alternative Medicine

Research Article

Efficacy of Boesenbergia rotunda Treatment against Thioacetamide-Induced Liver Cirrhosis in a Rat Model

Table 5

Effect of Br ethanol extract on serum protein, albumen, and globulin levels and prothrombin time ratio at the end of the 8-week study.
TreatmentProtein g/LAlbumen g/LBilirubin umol/LProthrombin time ratio
Group 1
(normal rats)		 7 6 . 5 8 ± 0 . 7 0 3 1 . 9 3 ± 0 . 6 4 1 . 2 0 ± 0 . 0 6 1 . 0 2 ± 0 . 0 0 6
Group 2
(rats with cirrhosis)		 5 9 . 9 2 ± 1 . 1 4 ** 1 1 . 2 2 ± 0 . 3 3 ** 4 . 9 8 ± 0 . 1 2 ** 1 . 3 8 ± 0 . 0 2 4 **
Group 3
(silymarin-treated rats)		 7 5 . 8 2 ± 0 . 7 0 3 2 . 3 8 ± 0 . 8 8 1 . 2 8 ± 0 . 0 7 1 . 0 2 ± 0 . 0 0 5
Group 4
(treatment with the BR extract at 250 mg/kg dose)		 6 3 . 3 7 ± 1 . 2 0 2 0 . 2 0 ± 0 . 2 0 * 2 . 8 5 ± 0 . 1 0 * 1 . 2 8 ± 0 . 0 0 9 *
Group 5
(treatment with the BR extract at 500 mg/kg dose)		 7 5 . 1 0 ± 1 . 0 7 * 2 9 . 3 8 ± 0 . 2 8 * 1 . 6 8 ± 0 . 0 5 * 1 . 0 3 ± 0 . 0 0 2 *
Means between the silymarin-treated Group 3, low-dose BR-treated Group 4, and high-dose BR-treated Group 5 had significant differences when compared with the cirrhosis control Group 2 with * 𝑃 < 0 . 0 0 1 and compared with the normal control Group 1 with ** 𝑃 < 0 . 0 0 1 .