Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway
Figure 5
Effect of GTE on the mitochondria/caspase pathway in H23/0.3 cells. (a) H23/0.3 cells were treated with various concentrations of GTE (0 mg/mL, 0.3 mg/mL, and 0.9 mg/mL) for 24 h. The protein expression of Bcl-2 and Bax was measured by western blotting. (b) H23/0.3 cells were treated with various concentrations of GTE (0 mg/mL, 0.3 mg/mL, and 0.9 mg/mL) for 24 h. The release of cytochrome c (Cyt-c) into the cytoplasm was detected by western blotting. (c) H23/0.3 cells were treated with various concentrations of GTE (0 mg/mL, 0.3 mg/mL, and 0.9 mg/mL) for 24 h. The cleavage of caspase-3 and PARP was detected by western blotting. Results are expressed as the mean ± SD of three independent experiments.
