Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice

Figure 6

Effects of CA and G-CA extracts on hepatic steatosis. Three weeks after beginning a high-fat diet, C57BL6 mice were orally administered CA or G-CA extract (200 mg/kg body weight) or PBS daily for 8 weeks. (a) Oil red O staining was performed on frozen liver sections. (b) Hepatic triglyceride (TG) content was measured in liver tissue. (c) ACC1, Fas, and SREBP1c mRNA levels were analyzed in liver tissue. Values are expressed as fold change compared with the NC group. Values are mean ± SE. NC: untreated, normal chow diet; PBS: PBS-treated, high-fat diet (HFD); CA: CA-treated, HFD; and G-CA: G-CA-treated, HFD. ^∗∗𝑃<0.01 compared with NC group. ^#𝑃<0.05, ^##𝑃<0.01 compared with PBS-HFD group.

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