Evidence-Based Complementary and Alternative Medicine

Research Article

Reversion of P-Glycoprotein-Mediated Multidrug Resistance in Human Leukemic Cell Line by Diallyl Trisulfide

Figure 4

Morphology observed by light microscopy.
719805.fig.004a
(a) K562/A02 cells grown 48 hours without drugs (400 magnification).  Cells proliferated actively, mitotic easy to see (shown with ↑)
719805.fig.004b
(b) K562/A02 cells grown 48 hours with adriamycin (1  ) (400 magnification).   Cells proliferated actively, mitotic easy to see (shown with ↑)
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(c) K562/A02 cells grown 24 hours with adriamycin and DATS (2  ) (400 magnification).   Proliferation of K562/A02 cells slowed down, mitotic rarely to see
719805.fig.004d
(d) K562/A02 cells grown 48 hours with adriamycin and DATS (400 magnification). K562/A02 cells showed cell shrinkage, chromatin condensation, margination, nuclear fragmentation, apoptotic bodies easy to see (shown with ↑)
719805.fig.004e
(e) K562/A02 cells grown 72 hours with adriamycin and DATS (400 magnification). Survival rate of K562/A02 cells reduced, apoptotic bodies easy to see (shown with ↑)