Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
Figure 4
BLTW : CD1(ICR) mice are protected from diet-induced glucose intolerance. (a) Glucose tolerance test (GTT) after 4 weeks of diet exposure by using an i.p. dose of 2 g of glucose per kg of body weight. (b) Values of the area under the curve (AUC) during GTT since the different basal plasma glucose levels, areas between glucose curves after glucose or insulin injection, and baseline glucose level curve (ΔAUC) were calculated. (c) Insulin tolerance test (ITT) after 4 weeks of diet exposure by using 0.5 IU/kg insulin. (d) ΔAUC during ITT. 6–8 per group; means ± SEM; *: versus Con; #: versus HF. (e) Glycogen content assay after 4 weeks of diet exposure by using 0.5 IU/kg insulin. 6–8 per group; means ± SEM; *: versus those treated with vehicle (V, grey bars); #: versus HF treated with insulin (I, black bars); Con: control mice; HF: mice fed with high fat and diet; HFCA or HC: HF mice treated with CAPA; HFMET or HM: HF mice treated with metformin.
