Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin

Table 1

Food and water intake of mice after 4 weeks of diet exposure.

	Basal	After 4 weeks of diet exposure
		Con	HF	HC	HM
Body weight (g)	25.6 ± 0.4	35.5 ± 0.8	40.2 ± 1.0^*	37.2 ± 0.6^#	35.0 ± 1.1^#
Night food intake (g)	4.5 ± 0.5	6.0 ± 0.5	4.3 ± 0.8^*	2.4 ± 0.3^#	2.4 ± 0.4^#
Night water intake (mL)	10.5 ± 0.6	12.2 ± 0.2	6.4 ± 0.6^*	5.9 ± 0.3	6.4 ± 0.5
Night calorie intake
Food (kcal)	14.4 ± 1.3	18.1 ± 1.4	19.8 ± 2.2	12.5 ± 0.9^#	11.1 ± 1.7^#
Water (kcal)	—	—	5.5 ± 0.3	4.1 ± 0.5	5.1 ± 0.4
Total (kcal)	14.4 ± 1.3	18.1 ± 1.4	25.3 ± 2.2^*	16.6 ± 0.8^#	15.9 ± 4.4^#

Con: control mice; HF: mice fed with high fat and diet; HC: HF mice treated with CAPA; HM: HF mice treated with metformin; ^*: P < 0.05 versus Con; ^#: P < 0.05 versus HF; n = 6–8 per group.