Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin

Table 2

Metabolism and ischemic injury of mice after 4 weeks of diet exposure.

	After 4 weeks of diet exposure
	Con	HF	HF2WCA2W	HF2WMET2W
Body weight (g)	35.5 ± 0.8	40.2 ± 1.0^*	39.7 ± 1.2^*	38.3 ± 0.7^*
Plasma insulin (pM)	117.5  ± 8.8	203.5  ± 21.1^*	148.3 ± 29.2^#	131.1 ± 20.5^#
Plasma glucose during IPGTT (mg/dL)
0 min after injection	109.2 ± 7.5	169.9 ± 4.5^*	149 ± 6.9^*,#	151.4 ± 8.5^*, #
30 min after injection	290.8 ± 31.5	359.0 ± 17.5^*	291.7 ± 2.4^*, #	271.8 ± 2.3^*, #
120 min after injection	172.2 ± 26.3	297.5 ± 20.5^*	166.7 ± 10.2^*, #	179.3 ± 5.2^*, #
Basal coronary flow (mL/min)	3.4 ± 0.5	1.6 ± 0.3^*	3.6 ± 0.4^#	2.5 ± 0.4^#
Infarct size of the heart after global ischemia/reperfusion (AAR%)	30.6 ± 5.1	39.4 ± 6.6^*	29.9 ± 4.8^#	30.0 ± 3.8^#

CAPA was introduced after 2 weeks of diet exposure and orally treated once a day for another 2 weeks. Con: control mice; HF: mice fed with high fat and diet; HF2WCA2W: HF mice treated with CAPA for another 2 weeks; HF2WMET2W: HF mice treated with metformin for another 2 weeks; AAR: area at risk; ^*: P  < 0.05 versus Con; ^#: P  < 0.05 versus HF; n = 6–8 per group.