Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin

Table 3

Metabolism and ischemic injury of mice after 4 weeks of STZ injection.

	After 4 weeks of STZ injection
	Con	STZ	S2WCA2W
Body weight (g)	35.5 ± 0.8	21.2 ± 2.9^*	24.0 ± 0.6^*, #
Plasma glucose (mg/dL)	113.5 ± 4.5	588.0 ± 34.5^*	483.2 ± 24.0^*, #
Plasma insulin (pM)	117.5 ± 8.8	8.3 ± 1.5^*	5.8 ± 1.0^*
Basal coronary flow (mL/min)	3.4 ± 0.5	1.5 ± 0.2^*	1.83 ± 0.3^*, #
Infarct size of the heart after global ischemia/reperfusion (% AAR)	30.6 ± 5.1	51.3 ± 2.5^*	37.1 ± 5.8^*, #

CAPA was introduced after 2 weeks of STZ injection and orally treated once a day for another 2 weeks. Con: control mice; STZ: streptozocin-induced type 1 diabetic mice; S2WCA2W: STZ mice treated with CAPA for another 2 weeks; AAR: area at risk; ^*: P  < 0.05 versus Con; ^#: P  < 0.05 versus STZ; n = 6–8 per group.