Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression

Figure 4

Effects of 3 weeks of EA stimulation on CUS-induced depressive-like behavior. (a)-(b) 2 Hz or 100 Hz EA stimulation had no effect on sucrose preference and sucrose intake. (c) Neither 2 Hz nor 100 Hz EA had any effect on immobility, climbing, and swimming in the FST. (d)–(f) In the OFT, 2 Hz EA induced significantly increased horizontal (d) and vertical (e) movement distances and center entries (f), while 100 Hz EA demonstrated no effect on the horizontal movement distance. 𝑛=8 per group. Data represent mean ± SEM, ^∗𝑃<0.05, and ^∗∗𝑃<0.01  versus the vehicle-treated group.

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