Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression

Figure 5

Effects of 3 weeks of combined treatment with EA and citalopram on CUS-induced depressive-like behavior. (a) Body weight. (b)-(c) 2 Hz EA plus 5 mg/kg citalopram as well as 10 mg/kg citalopram produced a substantial increase in sucrose preference without affecting the total fluid intake. (d) 2 Hz EA plus 5 mg/kg citalopram induced significantly decreased immobility time and increased climbing time in the FST. (e)–(g) 2 Hz EA plus 5 mg/kg citalopram led to significantly increased horizontal (e) and vertical (f) movement distances and center entries (g). 𝑛=8-9 per group. Data represent mean ± SEM, ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001  versus the vehicle-treated group.

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