Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 2 / Review Article
Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach Table 2 Effect of garlic on blood pressure levels.
Study Type Target Duration of Rx Dose Case/control Outcome Zhang et al., (2001) [48 ] Parallel-controlled trial Hypertensives 16 weeks Distilled garlic oil 12.3 mg/d 14/13 Garlic oil lowers SBP and DBP Dhawan and Jain, (2004) [49 ] Not placebo controlled Hypertensives 2 months Garlic pearls 250 mg 20/20 Dec Bp, dec ox-LDL, and 8-iso-PGF2alpha levels Capraz et al., (2007) [55 ] Randomized placebo control trial Hypertensives 70 minutes Rw garlic, Garlic tablets 25/25/25 No effects on BP levels Duda et al., (2008) [51 ] Prospective and uncontrolled clinical study Hypertensives 30 days Antihypertensive drug + Garlic capsules 38/32 Dec total lipids and lipid peroxidation noticed Ried et al., (2010) [50 ] Randomized placebo control trial Hypertensives 12 weeks 960 mg AGE 25/25 SBP—10.2 ± 4.3 mmHg dec Ried et al., (2013) [53 ] Double-blind, randomized placebo-controlled, dose-response trial Hypertensives 12 weeks Aged garlic 240/480/960 mg 26/26/27 SBP—11.8 ± 5.4 mmHg, (2 capsule) 7.4 ± 4.1 mmHg (4 capsule)
T. chol: total cholesterol, HDL: high density lipoprotein, TG: triglyceride, LDL: low-density lipoprotein, VLDL: very low-density lipoprotein, 8-OHdG: (8-Hydroxy-2′-deoxyguanosine), and 8-iso-PGF2alpha: (8-iso-Prostaglandin F2alpha).