Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts
Figure 4
(a) Genes regulated more than 2 folds by Jin treatment on H460 cells. Combined with ratio values 2-fold difference, in JIN group, significantly upregulated gene CDKN1C and downregulated genes including PTCH2, TCF7, and WSB1 passed statistic t-test. The results were reconfirmed by real-time PCR with CDKN1C and PTCH2 primer pairs. (b) Genes regulated more than 2 folds by DDP treatment on H460 cells. (c) The coformula treatment of JIN and DDP also involved the inhibition of the stress/heat shock pathway: HSPA4, HSF1, MYC, FOS, and so forth.
