Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Table 5

Effects of GE on enzymic antioxidants and MDA levels in the kidney and liver homogenates of C5BL/6J mice fed on a high-fat diet.

Groups		Antioxidant activity (nmol/min/mg protein)
		GPx	CAT	SOD (U/mg protein)	LPO (mmol/L)
ND	Kidney; Liver	71.08 ± 6.3^cd; 83.95 ± 10.8^b	103.93 ± 4.5^d; 29.96 ± 3.9^c	0.34 ± 0.0^d; 0.17 ± 0.0^b	0.89 ± 0.01^e; 0.76 ± 0.03^b
ND240	Kidney; Liver	82.72 ± 6.9^d; 90.42 ± 11.7^b	112.96 ± 4.6^e; 32.57 ± 6.7^d	0.37 ± 0.0^d; 0.32 ± 0.0^d	0.83 ± 0.04^d; 0.7 ± 0.1^ab
HFD	Kidney; Liver	32.31 ± 3.2^a; 45.22 ± 5.5^a	52.64 ± 1.2^a; 15.18 ± 8.7^a	0.017 ± 0.0^a; 0.01 ± 0.0^a	0.9 ± 0.04^e; 0.92 ± 0.1^c
HFD60	Kidney; Liver	32.46 ± 4.9^a; 68.20 ± 8.3^b	79.72 ± 1.3^b; 22.98 ± 5.7^b	0.23 ± 0.0^b; 0.19 ± 0.0^b	0.86 ± 0.02^de; 0.62 ± 0.1^a
HFD120	Kidney; Liver	36.16 ± 5.1^ab; 74.86 ± 8.7^b	86.40 ± 11.6^bc; 24.91 ± 9.7^bc	0.27 ± 0.0^c; 0.23 ± 0.0^bc	0.64 ± 0.03^b; 0.6 ± 0.04^a
HFD240	Kidney; Liver	44.58 ± 5.3^b; 61.39 ± 8.9^b	84.29 ± 1.5^bc; 24.30 ± 1.1^bc	0.22 ± 0.0^b; 0.26 ± 0.0^c	0.57 ± 0.04^a; 0.61 ± 0.06^a
HFDMET	Kidney; Liver	66.83 ± 5.5^c; 119.06 ± 9.3^c	89.49 ± 2.7^c; 25.80 ± 8.5^bc	0.20 ± 0.0^b; 0.19 ± 0.0^b	0.74 ± 0.03^c; 0.64 ± 0.05^ab

GE concentrations were 60, 120, and 240 mg/kg/day. Metformin (MET) is used as positive control. Values expressed are means ± S.D of triplicate measurements. For same antioxidant activity with various treatment groups, superscripts in the different bar with different alphabets (a–e) were significantly different (𝑃<0.05). Superscripts with same alphabets were not significantly different between the treated groups (𝑃>0.05). GPx is glutathione peroxidase; CAT is catalase; SOD is superoxide dismutase; LPO is lipid peroxidation.