Cardiovascular Effects of Salvianolic Acid B

Table 1

Antioxidant effect of salvianolic acid B in vitro.

Cells/tissues	Effects	Reference
ECV304	Activity of SOD,; release of NO,; aggregation of Ca^2+.	Luo et al., 2002 [18]
SCs	Generation of ROS,; generation of 8-OHDG,; expression of Bax,; AIF nuclear translocation,; cytochrome C release,; caspase of the enzyme 3, 9,; cleavage of PARP,; expression of Bcl-2.	Sun et al., 2012 [19]
HASMCs	Activity of gelatinolytic,; scavenge H2O2.	Zhang and Wang, 2006 [20]
SH-SY5Y	Scavenge O2^+ and OH,; reduce oxidative damage.	Liu et al., 2006 [21]

Note: HEK293T cell: human embryonic kidney cells; HO-1: heme oxygenase-1; ROS: reactive oxygen species; Nrf2: nuclear factor 2–related factor 2; SOD: superoxide dismutase; MDA: malondialdehyde; ECV304: human umbilical vein endothelial cells; TMP: tetramethylpyrazine; HASMCs: human aortic smooth muscle cells; 8-OHDG: 8-hydroxy-2-deoxyguanosine; SCs: Schwann cells; MMP-2: matrix metalloproteinase-2; PARP: poly ADP-ribose polymerase.