Cardiovascular Effects of Salvianolic Acid B

Table 11

Antiatherosclerosis of salvianolic acid B in vitro.

Cells/tissues	Effects	Reference
VSMCs	Nrf2-ARE signaling pathway,; activation of NQO1.	Hur et al., 2010 [71]
H-monDC	Supress activation of PPARγ nuclear translocation,; expression of CD40, CD86, CD1a, and HLA-DR,; expression of IL-12 and IL-10,; production of TNF-α,; regulation of TLR4,; myeloid differentiation of primary reactive protein 88,; p38-MAPK signaling pathway.	Sun et al., 2011 [72]
Macrophage	Reduce mLDL uptake,; antagonize CD36.	Bao et al., 2012 [73]
HASMCs	MMPs protein synthesis,; downregulate ERK1/2,; downregulate c-JNK.	Lin et al., 2007 [74]

Note: H-monDC: human monocyte-derived dendritic cells; Nrf2: nuclear factor 2-related factor 2; NQO1: NAD(P)H quinine oxidoreductase-1; PARP: poly ADP-ribose polymerase; ARE: antioxidant responsive element; VSMC: vascular smooth muscle cells; IL: interleukin; TLR: toll like receptor; TNF: tumor necrosis factor.