Cardiovascular Effects of Salvianolic Acid B

Table 2

Anti-platelet aggregation, anticoagulant, and antithrombotic effect of salvianolic acid B in vitro and in vivo.

Type	Cells/tissues	Effects	Reference
In vitro research	Human platelet; endothelial cell	Activity of eNOS,; L-arginine to L-citrulline,; release of NO.	Radomski et al., 1990 [25, 26]
	Platelet	Collagen receptor α2β1.	Wu et al., 2008 [29]
Type	Organ/animals	Effects	Reference
In vivo research	Rats blood; Rats blood	Induce SIPA.; 20 kinds of protein expression,; α2β1 integrin protein,; levels of intracellular Ca^2+,; cytoskeleton-related proteins,; cytoskeleton platelets structure.	Li et al., 2004 [28]; Ma et al., 2011 [23]

Note: eNOS: endothelial nitric oxide synthase; L-arginine: left-handed arginine; SIPA: shear-induced platelet aggregation.