Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas

Table 1

Lung tumorigenesis frequency of Tg/Mock and Tg/Andrographolide groups in the mouse lung tissues (𝑛=6) using histopathological image analysis.

Variable	Tg/Mock	Tg/Andrographolide
Normal	0 (0%)	2 (33.3%)
Cyst	6 (100%)	4 (66.7%)
Damaged alveoli	4 (66.7%)	2 (33.3%)
Mild emphysematous change	0 (0%)	3 (50%)
Prominent emphysematous change	6 (100%)	1 (16.7%)
Hemosiderin-laden macrophages in alveoli	2 (33.3%)	0 (0%)
Old hemorrhage	6 (100%)	2 (33.3%)
Moderate lymphocytic infiltration	0 (0%)	1 (16.7%)
Marked chronic lymphoid infiltration	6 (100%)	2 (33.3%)
Neoplasm	3 (50%)	1 (16.7%)
Lymphoma	6 (100%)	1 (16.7%)
Adenocarcinoma	5 (83.3%)	2 (33.3%)