Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice
Figure 5
Effects of paeonol on renal histology in mice. Sections of kidney were stained with H&E 72 h after cisplatin injection. Saline treatment alone (a); cisplatin treatment alone (b); paeonol and cisplatin treatment (c). Renal tubular injury was assessed using a semiquantitative score in which the percentage of cortical tubules showing epithelial necrosis was assigned a score of either 0, none; 1, <10%; 2, 10–25%; 3, 25–75%; or 4, >75% (d). Saline: saline alone; Cis: cisplatin alone; Cis + paeonol: paeonol pretreatment and cisplatin treatment ( versus Cis, ).
