Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice

Figure 6

Effects of paeonol on cisplatin-induced proinflammatory cytokines. Kidneys were obtained at 72 h after cisplatin injection, and cytokine levels of TNF-α (a) and IL-1β (b) were determined by ELISA. Saline: saline alone; Cis: cisplatin alone; Cis + paeonol: paeonol pretreatment and cisplatin treatment. Values shown are the mean ± S.E.M. Data were analyzed by a Student’s 𝑡-test (^∗𝑃<0.05, ^∗∗𝑃<0.01 versus Cis; 𝑛=4 for saline; 𝑛=5 for Cis or Cis + paeonol).

(a)

(b)