Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo
Figure 6
Inhibitory effects of AJW on 8-OHdG accumulation by MPTP in mice. Saline or AJW at 10 or 100 mg/kg/day were administered orally for 7 days, and MPTP 20 mg/kg was injected intraperitoneally four times at 2-h intervals on the last day of AJW treatment. After the behavioral tests, oxidative DNA damage in the cells of the SNc was detected using 8-OHdG-immunohistochemistry. The numbers of 8-OHdG-positive cells in the SNc were counted (a), and the representative images are shown ((b)–(e)). Control group (b), MPTP-only treated group (c), MPTP + AJW 10 mg/kg/day treated group (d), and MPTP + AJW 100 mg/kg/day treated group (e). Scale bar = 200 μm. Values are indicated as the mean ± SEM. *** compared with the control group, ### compared with the MPTP-only treated group.
