Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi
Figure 3
In vivo antitrypanosomal activity of the different treatments, determined by the number of amastigote nests observed in cardiac tissue from infected mice. CN: negative control, infected animals treated with PBS; CP: positive control, infected animals treated with allopurinol (8.5 μg/g); FHex: hexane fraction, animals treated with the hexane fraction from the leaf crude extract of S. yucatanensis (41.6 mg·kg−1·day−1); D1: dose 1, infected mice treated with a 20.8 mg·kg−1·day−1 1 : 4 mixture of lupenone and caryophyllene oxide; D2: dose 2, infected mice treated with a 41.6 mg·kg−1·day−1 1 : 4 mixture of lupenone and caryophyllene oxide. Statistical analysis was performed using one-way ANOVA and post hoc Tukey’s test: compared with negative control.
