Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction
Figure 2
Typical echocardiography images from the sham group (a), the MI group (b), the WXKL group (c), and the amiodarone group (d). At the 4th week of WXKL and amiodarone administration, cardiac structure and function were measured in each group by echocardiography. We evaluated cardiac systolic and diastolic functions by measuring the following variables: left ventricular end-diastolic dimension (LViDd) (e), left ventricular end-systolic dimension (LViDs) (F), end-diastolic volume (EDV) (g), end-systolic volume (ESV) (h), stroke volume (SV) (i), ejection fraction (EF) (j), and fractional shortening (FS) (k). Treatment with either WXKL or amiodarone improved systolic function. The rats of the sham group () and the MI group () were treated with vehicle (distilled water) alone (1 mL/kg/day); the WXKL group () were treated with 4 g/kg/day WXKL; and the amiodarone group () were treated with 30 mg/kg/day amiodarone. (* versus the MI group, ▲ versus the sham group).
