Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel

Figure 1

Effect of GA on the 𝐼_K of guinea pig ventricular myocytes. (a) Current traces elicited by 5 s test pulses from −10 to +80 mV with 10 mV increments, and tail currents recorded at −30 mV for 2 s. Representative traces of 𝐼_K recorded from the same cell under control condition and after applying GA. Current-voltage relationship of 𝐼_K,step (b) and 𝐼_K,tail (c) observed in five cells tested in the absence and presence of GA (1, 5, and 10 μM). Summary of the effects of GA (1, 5, and 10 μM) on 𝐼_K,step (d) and 𝐼_K,tail (e), normalized relative to the control current (𝑛=5, *𝑃<0.05, **𝑃<0.01).

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