Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated from Rhodiola rosea
Figure 5
Effects of R. rosea extract on cytokines mRNA expression in LPS-treated mice. ICR mice were orally administered with the R. rosea extract (500 mg/kg); 30 min later mice were injected (i.p.) by 1 mg/kg LPS. Expressions of iNOS, IL-1β, and TNF-α were measured by PCR analysis at 6 h or 16 h after LPS treatment. R. rosea extract suppressed the expression of iNOS, IL-1β, and TNF-α in mice 6 h later for kidney and 16 h later for prefrontal cortex of brain. β-actin was used as an internal control. All values are expressed as mean ± S.E.M. from three independent experiments. Data were analyzed by one-way ANOVA for multiple comparisons and Student-Newman-Keuls test as post hoc test. # as compared with the vehicle group; * as compared with the LPS injected group.
