Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug
Figure 3
Distribution of GO terms altered by EEDS treatment in A549 cells. (a) GO terms associated with differentially expressed genes that had a fold ratio greater than 2 or less than 0.5 (for up- and down-regulation, resp.) were analyzed at each dose of EEDS using the High-Throughput GoMiner tool. Columns represent individual samples, and rows represents statistically significant GO terms (). The positions of signaling-related pathways are colored red. Statistical significance is represented by a gray color gradient, as indicated by the scale bar. (b) A network composed of all nonredundant statistically significant GO terms () after EEDS treatment (20 μg/mL) was constructed using the REVIGO program. The size and color density of each GO term are proportional to its statistical significance, and edge thickness represents the relatedness between two nodes.
