Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug

Table 2

Top 20 list of genes mostly down-regulated or up-regulated by EEDS.

Down-pattern				Up-pattern
Symbol	EEDS (μg/mL)			Symbol	EEDS (μg/mL)
	1.25	5	20		1.25	5	20
CSRP2BP	−1.35^∗	−3.05	−6.16	HBEGF	0.86	1.58	4.44
SCARA5	−0.28	−2.58	−5.71	C7orf53	2.86	2.73	4.46
HOXB13	−0.66	−2.42	−5.06	SERPINE1	1.54	3.50	4.59
FOXS1	0.12	−2.40	−4.92	CD274	2.59	3.23	4.60
SNORA12	−2.24	−4.44	−4.91	NOG	1.16	3.91	4.67
RIMBP3	−2.00	−2.74	−4.89	PER1	2.22	1.52	4.68
ST6GAL1	−1.82	−2.20	−4.88	ARC	0.78	1.69	4.79
DACT2	−2.47	−4.08	−4.87	GADD45B	1.23	1.95	4.82
TMEM37	−1.42	−4.37	−4.85	LTB	1.37	4.06	4.85
EEF2K	−1.55	−2.50	−4.84	FOS	1.25	0.52	4.87
GPRIN2	−2.57	−3.41	−4.79	DDIT3	1.66	2.78	4.90
SALL2	−2.08	−4.10	−4.76	C3orf52	1.04	2.26	4.96
CBR3	−1.56	−3.26	−4.57	MAFF	1.62	2.70	5.07
FANCF	−1.30	−1.88	−4.56	IL8	2.94	4.52	5.55
CCR7	−0.58	−1.72	−4.47	PPP1R15A	1.42	2.61	5.59
C5orf58	−0.90	−1.72	−4.38	LOC387763	3.52	4.33	5.67
VAV3	−0.91	−3.48	−4.36	ATF3	1.02	2.49	5.69
C14orf93	−0.64	−2.00	−4.31	EGR2	0.11	0.72	6.46
NTHL1	−0.57	−2.05	−4.31	FOSB	1.36	3.75	7.85
VASH1	−1.31	−3.69	−4.28	EGR1	1.44	4.10	10.02

∗Fold induction represents log₂ expression ratio of gene compared with that of control.