Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug
Table 3
Clinical association of Down- or Up-pattern genes regulated by the EEDS with survival from lung cancer.
Down-pattern
Up-pattern
Symbol
Fold induction*
value**
Hazard ratio**
Symbol
Fold induction
value
Hazard ratio
HMBS
0.00225
1.41
YPEL5
1.99
0.000577
0.62
GMPPA
0.00283
1.46
MNT
1.56
0.00344
1.42
CD79A
0.00431
0.72
GGA3
1.11
0.00421
1.40
HSPA12A
0.00759
1.43
MGC29506
1.00
0.00471
0.72
RUNX3
0.00818
0.71
CHD7
1.63
0.00763
1.49
RBKS
0.0123
1.47
ERCC6
1.52
0.00887
1.37
LRRC20
0.0132
1.47
SSBP2
1.61
0.0122
0.72
RNF144A
0.0136
0.75
NUFIP1
1.41
0.0129
1.33
C11orf60
0.0148
1.36
CLK3
1.04
0.0159
1.37
BCS1L
0.0149
1.32
PPP1R13L
2.74
0.0160
1.35
CHST12
0.0155
0.75
TNFSF9
1.92
0.0162
1.34
CRYBB2P1
0.0172
0.75
DDX52
1.80
0.0163
1.36
APITD1
0.0176
1.35
FAM108B1
1.33
0.0192
0.73
AP1G2
0.0177
1.39
ZMYM5
1.23
0.0203
1.32
ALDH3B1
0.0185
1.36
PTPRH
1.89
0.0217
1.34
AUTS2
0.0210
0.74
BTG2
3.33
0.0231
0.74
NIPSNAP1
0.0229
1.29
ARHGEF15
1.52
0.0233
1.3
LCMT1
0.0240
1.29
SPATA2L
1.68
0.0244
1.30
HERC6
0.0250
0.75
PRKRIP1
1.56
0.0245
0.76
DYRK4
0.0261
0.77
KIFC1
1.47
0.0247
1.32
TPD52L1
0.0262
1.35
RUNX1
2.83
0.0247
1.32
VPS33B
0.0274
1.32
GOLGA8A
2.02
0.0249
0.72
DHRS1
0.0280
1.28
ABL1
1.15
0.0254
0.76
WDR61
0.0292
1.32
CRABP2
2.34
0.0258
0.75
PYGL
0.0314
1.31
DDIT3
4.91
0.0260
1.34
MKS1
0.0316
1.29
IP6K2
2.19
0.0273
0.76
VASH1
0.0336
0.77
LOC729806
1.2
0.0275
1.36
MRPL46
0.0338
1.29
ELL
2.63
0.0284
0.79
APBA2
0.0340
0.75
TRAF4
1.00
0.0294
1.39
LARGE
0.0341
0.76
SEMA7A
1.16
0.0297
1.31
IMP3
0.0354
1.28
PRNP
1.51
0.0303
0.75
AAAS
0.0354
0.78
GADD45A
4.03
0.0314
0.76
TGIF1
0.0359
1.26
GLIPR1
1.94
0.0330
0.77
C11orf80
0.0363
1.32
PAPOLG
1.93
0.0331
0.75
AGAP11
0.0387
1.33
ZNF484
2.81
0.0336
1.36
CCR7
0.0390
0.78
RAP2C
1.46
0.0336
0.76
RRBP1
0.0395
0.77
MED1
1.25
0.0389
1.24
CDC123
0.0422
1.29
HERPUD1
1.01
0.0392
0.79
REEP4
0.0433
1.28
DDR2
1.11
0.0404
0.79
PFKFB1
0.0433
0.78
PLK4
1.59
0.0417
1.30
ZNF839
0.0440
1.3
CDC42SE1
2.29
0.0417
0.76
CCDC53
0.0460
0.80
AOC2
1.09
0.0430
1.29
RDX
0.0466
1.29
RUNX2
1.80
0.0438
1.29
EIF2B3
0.0470
1.27
SFRS12IP1
1.81
0.0451
0.76
PAAF1
0.0471
1.35
INPP1
1.40
0.0456
0.76
PITPNC1
0.0483
1.29
MCAM
1.57
0.0458
0.79
ATIC
0.0492
1.27
LTB
4.85
0.0470
0.77
DDX28
0.0498
1.28
ZCCHC10
1.13
0.0480
0.79
SP2
1.59
0.0489
0.79
PTHLH
2.81
0.0499
0.79
Fold induction represents expression ratio of gene at treatment with 20 μg/mL of EEDS. Log-rank value and hazard ratio were measured in Cox-proportional hazard regression model performed in public lung cancer data [16].