Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug

Table 3

Clinical association of Down- or Up-pattern genes regulated by the EEDS with survival from lung cancer.

Down-pattern				Up-pattern
Symbol	Fold induction*	𝑃 value**	Hazard ratio**	Symbol	Fold induction	𝑃 value	Hazard ratio
HMBS	−2.06	0.00225	1.41	YPEL5	1.99	0.000577	0.62
GMPPA	−2.80	0.00283	1.46	MNT	1.56	0.00344	1.42
CD79A	−1.27	0.00431	0.72	GGA3	1.11	0.00421	1.40
HSPA12A	−1.18	0.00759	1.43	MGC29506	1.00	0.00471	0.72
RUNX3	−1.19	0.00818	0.71	CHD7	1.63	0.00763	1.49
RBKS	−1.17	0.0123	1.47	ERCC6	1.52	0.00887	1.37
LRRC20	−2.88	0.0132	1.47	SSBP2	1.61	0.0122	0.72
RNF144A	−1.37	0.0136	0.75	NUFIP1	1.41	0.0129	1.33
C11orf60	−1.30	0.0148	1.36	CLK3	1.04	0.0159	1.37
BCS1L	−1.12	0.0149	1.32	PPP1R13L	2.74	0.0160	1.35
CHST12	−2.05	0.0155	0.75	TNFSF9	1.92	0.0162	1.34
CRYBB2P1	−1.09	0.0172	0.75	DDX52	1.80	0.0163	1.36
APITD1	−2.35	0.0176	1.35	FAM108B1	1.33	0.0192	0.73
AP1G2	−1.62	0.0177	1.39	ZMYM5	1.23	0.0203	1.32
ALDH3B1	−1.77	0.0185	1.36	PTPRH	1.89	0.0217	1.34
AUTS2	−1.89	0.0210	0.74	BTG2	3.33	0.0231	0.74
NIPSNAP1	−1.64	0.0229	1.29	ARHGEF15	1.52	0.0233	1.3
LCMT1	−1.69	0.0240	1.29	SPATA2L	1.68	0.0244	1.30
HERC6	−1.18	0.0250	0.75	PRKRIP1	1.56	0.0245	0.76
DYRK4	−1.21	0.0261	0.77	KIFC1	1.47	0.0247	1.32
TPD52L1	−1.30	0.0262	1.35	RUNX1	2.83	0.0247	1.32
VPS33B	−1.05	0.0274	1.32	GOLGA8A	2.02	0.0249	0.72
DHRS1	−1.83	0.0280	1.28	ABL1	1.15	0.0254	0.76
WDR61	−1.26	0.0292	1.32	CRABP2	2.34	0.0258	0.75
PYGL	−1.62	0.0314	1.31	DDIT3	4.91	0.0260	1.34
MKS1	−1.08	0.0316	1.29	IP6K2	2.19	0.0273	0.76
VASH1	−4.29	0.0336	0.77	LOC729806	1.2	0.0275	1.36
MRPL46	−1.52	0.0338	1.29	ELL	2.63	0.0284	0.79
APBA2	−2.56	0.0340	0.75	TRAF4	1.00	0.0294	1.39
LARGE	−2.96	0.0341	0.76	SEMA7A	1.16	0.0297	1.31
IMP3	−1.40	0.0354	1.28	PRNP	1.51	0.0303	0.75
AAAS	−1.55	0.0354	0.78	GADD45A	4.03	0.0314	0.76
TGIF1	−1.41	0.0359	1.26	GLIPR1	1.94	0.0330	0.77
C11orf80	−1.03	0.0363	1.32	PAPOLG	1.93	0.0331	0.75
AGAP11	−1.51	0.0387	1.33	ZNF484	2.81	0.0336	1.36
CCR7	−4.47	0.0390	0.78	RAP2C	1.46	0.0336	0.76
RRBP1	−1.05	0.0395	0.77	MED1	1.25	0.0389	1.24
CDC123	−1.09	0.0422	1.29	HERPUD1	1.01	0.0392	0.79
REEP4	−1.48	0.0433	1.28	DDR2	1.11	0.0404	0.79
PFKFB1	−1.40	0.0433	0.78	PLK4	1.59	0.0417	1.30
ZNF839	−2.28	0.0440	1.3	CDC42SE1	2.29	0.0417	0.76
CCDC53	−1.88	0.0460	0.80	AOC2	1.09	0.0430	1.29
RDX	−1.22	0.0466	1.29	RUNX2	1.80	0.0438	1.29
EIF2B3	−2.05	0.0470	1.27	SFRS12IP1	1.81	0.0451	0.76
PAAF1	−1.81	0.0471	1.35	INPP1	1.40	0.0456	0.76
PITPNC1	−1.39	0.0483	1.29	MCAM	1.57	0.0458	0.79
ATIC	−1.31	0.0492	1.27	LTB	4.85	0.0470	0.77
DDX28	−1.63	0.0498	1.28	ZCCHC10	1.13	0.0480	0.79
				SP2	1.59	0.0489	0.79
				PTHLH	2.81	0.0499	0.79

∗Fold induction represents log₂ expression ratio of gene at treatment with 20 μg/mL of EEDS.
∗∗Log-rank 𝑃 value and hazard ratio were measured in Cox-proportional hazard regression model performed in public lung cancer data [16].