Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug

Table 4

Top 10 GO terms associated with Up- and Down-patterns by EEDS treatment.

GO ID	GO terms	𝑃 value*	FDR**
Down-pattern
GO:0051188	Cofactor biosynthetic process	9.26𝐸−08	2.57𝐸−04
GO:0051186	Cofactor metabolic process	1.79𝐸−07	2.49𝐸−04
GO:0018130	Heterocycle biosynthetic process	8.03𝐸−07	7.42𝐸−04
GO:0044271	Nitrogen compound biosynthetic process	6.15𝐸−06	4.25𝐸−03
GO:0006399	tRNA metabolic process	1.65𝐸−05	9.12𝐸−03
Up-pattern
GO:0045449	Regulation of transcription	4.21𝐸−26	1.55𝐸−22
GO:0006350	Transcription	3.75𝐸−21	6.91𝐸−18
GO:0006355	Regulation of transcription, DNA-dependent	3.11𝐸−14	3.82𝐸−11
GO:0051252	Regulation of RNA metabolic process	3.78𝐸−14	3.49𝐸−11
GO:0006357	Regulation of transcription from RNA polymerase II promoter	2.05𝐸−13	1.51𝐸−10
GO:0042325	Regulation of phosphorylation	2.03𝐸−11	1.25𝐸−08
GO:0051173	Positive regulation of nitrogen compound metabolic process	2.39𝐸−11	1.26𝐸−08
GO:0045859	Regulation of protein kinase activity	2.44𝐸−11	1.12𝐸−08
GO:0019220	Regulation of phosphate metabolic process	2.68𝐸−11	1.10𝐸−08
GO:0051174	Regulation of phosphorus metabolic process	2.68𝐸−11	1.10𝐸−08

^∗𝑃 values were calculated using Fischer’s test.
∗∗FDR corrections were calculated using the Benjamini-Hochberg procedure in DAVID program [17].