Xiao-Xu-Ming Decoction Protects against Blood-Brain Barrier Disruption and Neurological Injury Induced by Cerebral Ischemia and Reperfusion in Rats
Figure 7
MMP-9, MMP-2, and VEGF immunohistochemistry in the ischemic cortex 24 h after reperfusion. (a) Representative images of MMP-9 immunohistochemistry in different groups. The images showed intense staining of neurons, glial cells, and cerebral vessels after ischemia and reperfusion. However, there were fewer stained neurons and glial cells in the XXMD60 group than in the IR group. (b) Representative images of MMP-2 immunohistochemistry. In the sham group, there was less staining in the cortex. MMP-2 immunostaining was enhanced 24 h after reperfusion in the IR group. The intensity of the MMP-2 staining was reduced in the XXMD60 group, with only a small number of strongly stained neurons and astrocytes. (c) Representative images of VEGF immunohistochemistry. There was almost no staining in the cortex in the sham group. VEGF immunostaining was intensely increased in ischemic cerebral vessels, neurons and reactive astrocytes in the IR group. In the XXMD treatment groups, VEGF immunostaining was reduced in intensity with a similar pattern for cell bodies and processes as in the IR group. , scale bar = 20 μm.
