Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice

Figure 1

The effect of Ixeris dentata NAKAI (ID) on dextran-sodium-sulfate- (DSS-) induced clinical signs. Ulcerative colitis was induced in female BALC/c mice by administering 5% DSS in the drinking water for seven days. Over the same period, ID (100 mg/kg) and the reference compound sulfasalazine (SFZ; 100 mg/kg) were given orally once daily. (a) Body weights were measured at the same time of the experimental days. (b) Colons were harvested on day 7, and colon lengths were measured. (c) Colon lengths in the four study groups. (d) Disease activity index scores in the four study groups. Values represent mean ± S.E.M. (𝑛=5). Data were analyzed by Student’s 𝑡 test (^#𝑃<0.05 versus control and ^∗𝑃<0.05 versus DSS alone).

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