Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice
Figure 4
The effects of Ixeris dentata NAKAI on epithelial injury and mast cells infiltration in dextran-sodium-sulfate- (DSS-) induced colitis. Ulcerative colitis was induced in female BALC/c mice by administering 5% DSS in the drinking water for seven days. Over the same period, ID (100 mg/kg) and the reference compound sulfasalazine (SFZ; 100 mg/kg) were given orally once daily. (a) Paraffin sections of colonic tissue were stained with hematoxylin and eosin (100x) or with toluidine blue for mast cell identification. Mast cell infiltration is indicated by the arrows (structures: TA, tunica adventitia; MM, muscularis mucosa; SL, submucosa layer; ML, mucosa layer; LU, lumen). Microscopic scores (b), thickness of mucosal layer (c), and number of mast cells (d) were presented. Values represent mean ± S.E.M. (). Data were analyzed by Student’s test ( versus control and versus DSS alone).
