Research Article
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
Table 1
Antiplasmodial activities and cytotoxicities of fractions of Cocos nucifera husk fibre extracts.
| | Extracts | IC50 (µg/mL) Plasmodium falciparum W2 | Remark | MLD50 (µg/mL)* | Selectivity index | | Hypoxanthine |
HRP2 | Mean |
| | DG (H) | >50.00 | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | DG (M) | — | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | DR (EA) | >50.00 | >50.00 | >50 | Inactive | 452.50 ± 136.50 | — | | DR (H) | 43.00 | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | DR (M) | >50.00 | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | DY (EA) | 9.80 | >50.00 | — | Inconclusive | >1000.00 ± 0.00 | — | | DY (M) | >50.00 | >50.00 | >50.00 | Inactive | 635.70 ± 48.50 | — | | DY (H) | >50.00 | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | HB (EA) | >50.00 | >50.00 | >50.00 | Inactive | 332.70 ± 33.00 | — | | HB (H) | >50.00 | >50.00 | >50.00 | Inactive | >1000.00 ± 0.00 | — | | HB (M) | >50.00 | 26.70 | — | Inactive | >1000.00 ± 0.00 | — | | WAT (EA) | 12.44 | 9.43 | 10.94 ± 2.00 | Active | 333.00 ± 25.50 | 30.30 | | WAT (H) | 46.60 | 30.50 | 39.00 ± 8.00 | Inactive | 408.00 ± 42.40 | — | | WAT (M) | 14.60 | >50.00 | — | Inconclusive | >1000.00 ± 0.00 | — | | Chloroquine | 0.04 | 0.05 | 0.04 ± 0.02 | Active | 387.50 ± 47.50 | 9687.50 |
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Mean of 3 experiments ± SD. WAT: West African Tall variety; DG: Dwarf Green variety; DR: Dwarf Red variety; DY: Dwarf Yellow variety; HB: Hybrid variety; M: methanolic fraction; H: hexane fraction; EA: ethyl acetate fraction.
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