Doinseunggitang Ameliorates Endothelial Dysfunction in Diabetic Atherosclerosis

Figure 5

Effect of DYSGT on (a) ET-1, (b) ICMA-1, and (c) eNOS immunoreactivity in aorta of ApoE KO mice. Immunohistochemical staining of ET-1, ICMA-1, and eNOS in aorta from cont., ApoE KO mice, ApoE mice treated with rosiglitazone, and ApoE mice treated with DYSGT. (d) Quantitative analysis of ET-1, ICMA-1, and eNOS positive area, respectively. The average score of 5–8 randomly selected sites per section of aorta was calculated. Data expressed as mean ± S.E.; **𝑃<0.01 versus cont.; ^#𝑃<0.05, ^##𝑃<0.01 versus ApoE KO. Original magnification, 100x and 400x.