Research Article
Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes
Table 2
PCR array analysis of expression change in selected atherosclerosis-related genes.
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Gene name | Fold change# | Diabetes | PPD-fed diabetic group (30 mg/kg/day) | PPT-fed diabetic group (30 mg/kg/day) |
| Adhesion molecules | | | | Selectin (platelet) | +2.33 | +1.18 | +1.29 | Intercellular adhesion molecule 1 | +2.06 | +1.46 | +1.46 | Macrophages | | | | Chemokine (C-C) motif ligand 2 | +2.49 | +0.56 | +0.47 | Chemokine (C-X-C) motif ligand 1 | +3.19 | +0.89 | +0.58 | Interleukin 1 receptor, type II | +3.28 | +1.22 | +1.38 | Interleukin 3 | +0.95 | +0.48 | +0.82 | Interleukin 4 | +1.23 | +0.53 | +0.83 | Interleukin 5 | +1.08 | +0.78 | +0.79 | Tumor necrosis factor-α | +1.56 | +1.31 | +1.03 | Lipid metabolism | | | | Apolipoprotein E | +1.53 | +2.95 | +2.50 | Lipase | +13.85 | +24.93 | +8.82 | Peroxisome proliferator-activated receptor-γ | +2.54 | +5.83 | +2.06 | Cell growth and migration | | | | Fibrinogen beta chain | +0.93 | +0.43 | +0.62 | von Willebrand factor homolog | +4.45 | +3.33 | +2.99 | Heparin-binding EGF-like growth factor | +2.53 | +1.95 | +2.04 | Laminin α 1 | +0.93 | +0.64 | +0.61 | Extracellular matrix (ECM) | | | | Fibronectin | +2.91 | +1.94 | +1.66 | Apoptosis | | | | Bcl2-like 1 | +0.73 | +0.75 | +0.83 | BH3 interacting domain death agonist | +1.45 | +1.25 | +1.23 |
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Fold changes (comparing to control group, fold change = 1) are calculated according to manufacturer’s analysis software.
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