Systematic Review of Compound Danshen Dropping Pill: A Chinese Patent Medicine for Acute Myocardial Infarction

Table 3

Characteristics of included studies.

ID	Sample size; (𝐼/𝐶)	Age; (y, 𝐼/𝐶)	Diagnostic; criteria of AMI	Type of; AMI	Intervention	Control	Duration of; treatment	Follow up	Outcomes	Baseline report
Li et al. 2011 [19]	500 (252/248)	60.10 ± 9.60/; 56.70 ± 7.80	Not specified	STEMI	CDDP 10 pills tid + CT; (the same as control)	CT (western medicines; + PCI)	30 days	30 days	All-cause mortality, shock,; arrhythmia, LVEF%, HF,; angina, myocardial enzyme.	Yes
Lin 2011 [33]	90 (46/44)	43–75/36–72	ACC/AHA; 2004	Unclear	CDDP 10 pills tid + CT (the same as control)	CT (western medicines)	6 weeks	6 weeks	LVEF%, WBC, CRP,; Chinese symptoms.	Yes; (narrative only)
Ma 2010 [35]	163 (78/85)	62.55 ± 11.95/; 66.02 ± 11.40	Not specified	STEMI	CDDP 10 pills tid + CT (the same as control)	CT (western medicines or; plus PCI/thrombolysis)	1 month	3 months	All-cause mortality, IL-6,; cardiac mortality, hs-CRP,; MACEs, MMP-9, TNF-a.	Yes
Li et al. 2010 [36]	63 (42/21)	58.40 ± 11.60	Not specified	Unclear	CDDP 10 pills tid + CT (the same as control)	Placebo + CT (western; Medicines + thrombolysis).	4 months	4 months	Cardiac mortality, LVEF%,; readmission, QOL, RMI,; HF, angina, adverse events.	Yes; (narrative only)
Guo et al. 2010 [20]	136 (76/60)	55.60 ± 12.5/; 51.80 ± 13.60	WHO	Unclear	CDDP 10 pills tid + CT (the same as control)	CT (western medicines; + thrombolysis)	4 weeks	4 weeks	All-cause mortality, shock,; HF, recanalization, angina,; myocardial enzyme.	Yes; (narrative only)
Xu and Wang 2007 [21]	218 (66/72/80)	36–75/37–78; /32–79	WHO	With; Q-wave	CDDP 10 pills tid d1-60, then 5 pills tid + CT (the same as control)	Propranolol 10∼15 mg tid + CT (no detail); CT (no detail)	12 months	12 months	All-cause mortality, RMI,; cardiac mortality, HF,; arrhythmia, LVEF%.	Yes; (narrative only)
Mei et al. 2006 [34]	45 (23/22)	56.11 ± 11.13	Not specified	Unclear	CDDP 10 pills tid + CT (the same as control)	CT (western medicines)	6 months	6 months	LVEF%, SV, CO	Unclear

Notes: CT: conventional therapy; HF: heart failure; AHA: American heart Association; ACC: American College of Cardiology; CRP: C-reactive protein; hs-CRP: high sensitive C-reactive protein; WBC: white blood cell; MACEs: major adverse cardiac events; WHO: World Health Organization; TNF-α: tumor necrosis factor-alpha; MMP-9: matrix metalloproteinase-9; IL-6: interleukin-6; SV: stroke volume; CO: cardiac output; tid: three times a day.