Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition

Table 2

Light microscopic and immunofluorescent findings of kidney histological lesions.

Groups	𝑁	Cell number per glomerulus	Case of mesangial proliferation (per 10 glomeruli)	Tubulointerstitial injury scores	IgG deposition (% positive area in glomerulus)
N	10	72.92±12.52	0.30±0.48	0	8.17±3.52
M	10	99.28±18.83^∗∗	4.73±1.43^∗∗	1.20±1.25^∗∗	45.86±7.97^∗∗
MMF (20 mg/kg)	10	103.04±21.69	3.40±2.46	1.20±0.76	21.99±6.64^##
Skimmin (15 mg/kg)	10	110.92±29.38	1.10±0.88^##	1.27±1.56	36.17±4.76^##
Skimmin (30 mg/kg)	10	81.80±17.92^##	1.20±1.34^##	0.33±0.47^#	26.00±5.376^##

Note: ^∗∗𝑃<0.01, versus normal control; ^#𝑃<0.05, ^##𝑃<0.01, versus model control, by One Way-ANOVA followed by post hoc test.