The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions

Table 2

The effects of CP-001 on the CYP enzyme activities without preincubation.

P450 isozyme	Remaining activities (% of control)					IC50
	CP-001 (μg/mL)
	1	3	10	30	100
CYP1A2	101.6	116.1	87.5	95.6	78.3	>100
CYP2A6	83.9	81.4	85.4	88.8	94.2	>100
CYP2D6	84.5	90.1	88.1	80.4	75.2	>100
CYP2C9	122.0	130.1	93.6	111.5	108.0	>100
CYP2C19	79.4	87.1	81.8	76.8	62.0	>100
CYP3A4	87.8	96.1	86.3	88.8	85.2	>100