Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals

<table>Structures of the main components isolated from Okinawan propolis and HPLC profile of EEOP. (a) Nymphaeol-A; (b) nymphaeol-B; (c) isonymphaeol-B; (d) 3′-geranyl-naringenin; (e) nymphaeol-C; naringenin, and eriodictyol. HPLC conditions: column, Capcell Pak UG120 C18 column (250 × 4.6 mm i.d.; Shiseido, Tokyo, Japan); flow rate, 1.0 mL/min; detection, 280 nm; solvent, (A) water with 0.1% trifluoroacetic acid (B) acetonitrile with 0.1% trifluoroacetic acid (B); gradient, 10–100% (B) in 60 min.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals 

Figure 1 | Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals 