Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals

<table>Angiotensin II reverses inactivation of ERK1/2 by nymphaeol-A. HUVECs were pretreated with 1 <i>μ</i>M angiotensin II, an ERK1/2 activator, for 3 h. Pretreated cells were incubated with nymphaeol-A at the indicated concentrations for 3 h. Caspase-3/7 activity was measured using the Caspase-Glo Assay Kit by luminescence assays as described in the text. *<svg height="11.375" id="M4" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, as compared with the control group.</table>

Evidence-Based Complementary and Alternative Medicine

fig10

Figure 10

Figure 10: Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals 

Figure 10 | Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals 