Antiatopic Dermatitis Effect of Artemisia iwayomogi in Dust Mice Extract-Sensitized Nc/Nga Mice
Figure 3
A. iwayomogi (AI) extract reduced the dermatitis scores and histological changes in D. farinae extract-sensitized Nc/Nga mice. (a) Macroscopic changes following the consecutive administration of AI or Protopic ointment onto D. farinae-induced, AD-like lesions on the back and ears in Nc/Nga mice. The images show the backs and ears for four weeks after sensitization. (b) The dermatitis scores of D. farinae-induced, AD-like skin lesions on the backs and ears (mean ± SEM , and , compared with the normal group, , compared with the D. farinae-induced control group). AI (10 mg/mouse/day) and Protopic ointment (50 mg/mouse/day) were topically applied on the back and ears once daily for four weeks. (c) Histological features of the back and ears. The tissues were stained with hematoxylin and eosin (H and E) or toluidine blue to estimate epidermal inflammation or mast cell infiltration. The mast cells are indicated by arrows.
