Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats

Figure 1

Changes of serum liver injury biomarkers and histopathology in swertianlarin-treated BDL rats. (a) Changes in ALT, AST, and ALP levels in sham rats with saline, BDL rats without swertianlarin, and BDL rats with swertianlarin for 3, 7, and 14 d. (b) Alterations of biomarkers TBIL, DBIL, and TBA levels in sham rats with saline, BDL rats without swertianlarin, and BDL rats with swertianlarin for 3, 7, and 14 d. (c) Liver histopathology (4X) in BDL rats with or without swertianlarin for 14 d. Data were analyzed using one-way analysis of variance followed by Dunnett’s multiple comparison post hoc test. versus sham group with saline; , versus BDL group with saline. per group. Saline, 1% Tween-20 saline; swertianlarin dissolved in 1% Tween-20 saline.

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