Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats

Figure 3

Alterations of serum bile salts by swertianlarin in BDL rats. (a) The concentrations of serum CDCA and TCDCA in sham operated rats and BDL rats with or without swertianlarin for 3, 7, and 14 d. (b) The changes in serum bile salts CA and TCA in sham operated, BDL with swertianlarin, and BDL without swertianlarin groups for 3, 7, and 14 d. (c) The determination of serum DCA and TDCA in sham operated rats and BDL rats treated with or without swertianlarin after 3, 7, and 14 d. (d) Serum TUDCA, (e) Tα/βMCA, and (f) αMCA and βMCA were measured in sham operated group, BDL with swertianlarin group, and BDL without swertianlarin group for 3, 7, and 14 d. Data were analyzed as described in Materials and Methods. versus sham group with saline; , versus BDL group with saline. per group. Saline, 1% Tween-20 saline; swertianlarin dissolved in 1% Tween-20 saline.

(a)

(b)

(c)

(d)

(e)

(f)