Jie-Du-Hua-Yu Granules Promote Liver Regeneration in Rat Models of Acute Liver Failure: miRNA-mRNA Expression Analysis

Figure 3

Selected miRNAs and potential target genes after treatment with JDHY granules. (a) 23 downregulated miRNAs, fold change ≤ −2 (). (b) 39 upregulated miRNAs, fold change ≥2 (). HemL software was used to depict the expressional changes of the miRNAs after treatment with JDHY granules. Columns represent the expression levels of each miRNA. Changes from low to high are depicted as a color variation from blue to red. (c) TargetScan and miRanda were used to predict miRNA target genes (the number of downregulated miRNAs: 23; the number of upregulated miRNAs: 39). Data were combined with the mRNA profile to select genes that changed ≥1.5 fold or ≤1.5 fold. According to the miRNA-mRNA expression pattern to select target genes (miRNA downregulated and mRNA upregulated, miRNA upregulated and mRNA downregulated), 32 genes were selected as potential target genes. HemL software was used to depict the expressional changes of each mRNA. Each column represents the mRNA expression level. Fold changes from low to high are depicted as color variations from blue to red.