Epileptic encephalopathies in children are severe disorders in which cognitive, sensory, and motor development is impaired by recurrent clinical seizures or prominent interictal epileptiform discharges. They include Ohtahara syndrome, early myoclonic epileptic encephalopathy, West syndrome, Dravet syndrome, Lennox-Gastaut syndrome, myoclonic-atonic epilepsy, continuous spike-wave in slow sleep, Rasmussen encephalitis, and other diseases. We summarize recent updates on the clinical, electrophysiological, neuroimaging, biochemical, and genetic findings in epileptic encephalopathies in children.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the genetic underlying epileptic encephalopathies in children, the clinical and EEG characterization of such conditions, the development of strategies to treat these conditions, and the evaluation of outcomes. Potential topics include, but are not limited to:

• A genetic diagnostic approach to epileptic encephalopathies in children
• EEG of age-dependent epileptic encephalopathy in infancy and early childhood
• Vitamin-responsive epileptic encephalopathies
• Infantile spasms: an update
• Lennox-Gastaut syndrome—an update
• Continuous spike-wave during slow wave sleep and related conditions
• Ketogenic diet—role in epileptic encephalopathies
• Surgical options for epileptic encephalopathies in children
• What pathophysiological mechanisms result in the progressive encephalopathy?
• How do these disorders evolve with age?

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