Research Article
Evaluation of the Clinical Effects and Frequency of MEFV Gene Mutation in Patients with Inflammatory Bowel Disease
Table 4
Effect of MEFV mutations on clinical variables.
| | Variables | Mutation (+)/ | Mutation (-)/ | value |
| UC, | Surgical requirement | 3/8 | 2/47 | 0.018 | Biologic agent requirement | 1/8 | 9/47 | >0.999 | Immunomodulator requirement | 3/8 | 23/47 | 0.708 | Steroid usage | 3/8 | 27/47 | o.446 | Recurrent disease | 3/8 | 16/47 | >0.999 | UC localization | Extensive colitis | 5/8 | 30/47 | >0.999 | Left colitis (+proctitis) | 3/8 | 17/47 | Extraintestinal manifestations | 7/8 | 41/47 | >0.999 | Age of onset of the disease () | | | 0.558 |
| CD, | Surgical requirement | 5/12 | 9/33 | 0.470 | Biologic agent requirement | 6/12 | 14/33 | 0.651 | Immunomodulator requirement | 11/12 | 26/33 | 0.419 | Steroid usage | 10/12 | 24/33 | 0.699 | Recurrent disease | 9/12 | 17/33 | 0.158 | CD localization | İleal | 5/12 | 10/33 | 0.496 | Colonic and ileocolonic | 7/12 | 23/33 | CD behavior | Fibrotic | 3/12 | 5/33 | 0.661 | Others | 9/12 | 28/33 | Fistulizing | 3/12 | 11/33 | 0.725 | Others | 9/12 | 22/33 | Perianal disease | 3/12 | 9/33 | >0.999 | Extraintestinal manifestations | 9/12 | 27/33 | 0.682 | Age of onset of the disease () | | | 0.253 |
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CD: Crohn’s disease; UC: ulcerative colitis; MEFV: Mediterranean Fever gene.
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