Identifying the Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treating Acute Liver Failure Based on Network Pharmacology and Molecular Docking

Table 3

Core targets of PCRR in the treatment of ALF and the topological parameters.

Uniport ID	Gene symbol	Degree	Betweenness	Closeness
P04637	TP53	40	0.11	0.49
P31749	AKT1	39	0.11	0.49
P05412	JUN	36	0.09	0.50
P07900	HSP90AA1	35	0.08	0.48
P28482	MAPK1	34	0.12	0.50
Q04206	RELA	33	0.06	0.49
P01375	TNF	28	0.06	0.46
P03372	ESR1	26	0.04	0.46
P05231	IL6	25	0.04	0.44
P01106	MYC	24	0.03	0.46
Q16539	MAPK14	23	0.02	0.46
P01100	FOS	23	0.04	0.46
P06400	RB1	22	0.02	0.45
P38936	CDKN1A	21	0.01	0.43
P00533	EGFR	21	0.03	0.44

PCRR: Polygoni Cuspidati Rhizoma et Radix; ALF: acute liver failure.