Research Article

Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification

Table 3

Ten key targets of ABM in treating NAFLD.

No.Gene symbolDescriptionDegree (DC)Betweenness centrality (BC)

1AKT1RAC-alpha serine/threonine-protein kinase760.09007483
2IL6Interleukin-6750.06038545
3TNFTumor necrosis factor720.04427747
4TP53Cellular tumor antigen p53660.02811782
5JUNTranscription factor AP-1610.01848417
6PTGS2Prostaglandin G/H synthase 2590.01631192
7CXCL8Interleukin-8590.01898645
8MAPK8Mitogen-activated protein kinase 8580.01679413
9MMP9Matrix metalloproteinase-9570.02436033
10CASP3Caspase-3570.01529514