Review Article

An Updated Meta-analysis: Similar Clinical Efficacy of Anterior and Posterior Approaches in Peroral Endoscopic Myotomy (POEM) for Achalasia

Table 1

Characteristics of included studies.

StudyCountryType of studySite of myotomyAge, mean/median (range/SD)Patients()Gender (male/female)Follow-up (months)Achalasia(I/II/III)Course of disease (months)

Hungness et al. [26]USARetrospective (cohort)Anterior52.9 (18)11268/4429 (11)25/58/20NA
Shiwaku et al. [27]JapanProspective (cohort)Anterior48.8 (18.8)7041/29NA6/55/9NA
Tang et al. [28]ChinaRetrospective (cohort)Anterior34.9 (7.7)2214/8125/17/06.4 (5.4)
38.5 (11.3)3920/1913/26/06.5 (4.8)
Ward et al. [29]USAProspective (cohort)Anterior63.0 (17.9)4125/1612NA81.6 (117.6)
Werner et al. [30]Germany, etc.Retrospective (cohort)Anterior44.9 (9–88)8043/3729 (24–41)24/48/5NA
Zheng et al. [31]ChinaRetrospective (cohort)Anterior32.5 (8.36)2614/121211/15/022.31 (8.31)
de Pascale et al. [32]ItalyRetrospective (cohort)Posterior56 (18–83)3220/1223.7 (12–46.2)0/31/136 (6.0–312)
Duan et al. [33]ChinaRetrospective (cohort)Posterior43 (14)7033/3730 (24-46)12/51/760.0 (6.0–396.0)
41 (13)5330/239/39/554.0 (6.0–240.0)
Farias et al. [34]BrazilRetrospective (cohort)Posterior53.70 (11.74)209/1112NANA
44.61 (14.80)3115/1612NANA
Guo et al. [35]ChinaRetrospective (cohort)Posterior40.7 (15.3)6736/3140.1 (2.8)13/50/494.7 (95.5)
Meng et al. [36]ChinaRetrospective (cohort)Posterior44.8 (11.6)3213/1925 (11)5/18/924 (12–60)
Peng et al. [37]ChinaRetrospective (cohort)Posterior37.5 (13.0)138/546.2 (4.1)NA46.8 (33.6)
Tyberg et al. [38]USA, etc.Prospective (cohort)Posterior54.25124/2724.4 (12–52)13/29/6134.4
Wang et al. [39]ChinaRetrospective (cohort)Posterior67.9 (4.3)2112/921.85/16/0166.8 (140.4)
Zhang and Linghu [40]ChinaRetrospective (cohort)Posterior43.3 (16–79)3216/1627 (24–51)0/0/3224.0 (2.4–336.0)
Ramchandani et al. [41]IndiaRCTAnterior38 (13.5)3015/1565/21/422.2 (28.1)
Posterior43.9 (15.7)3018/126/21/335.6 (37.6)
Stavropoulos et al. [42]USARCTAnterior54.2 (2)10152/49NA22/58/21NA
Posterior54.8 (1.8)11460/54NA36/56/22NA
Tan et al. [43]ChinaRCTAnterior45.8 (12.2)3115/1615.8 (3.8)4/26/180.4 (80.4)
Posterior42.4 (13.3)3214/1815.1 (3.9)3/28/174.4 (86.4)
Ichkhanian et al. [44]USA, etc.Prospective (cohort)Anterior52.3 (21)5429/2534.5 (6.9)13/33/853.3 (61.4)
Posterior51.2 (18)5723/3432.5 (5.2)4/42/1150.5 (59.9)